The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia

Mutations or deregulated expression of the components of the spliceosome can influence the splicing pattern of several genes and contribute to the development of tumors. In this context, we report that the spliceosome modulator sudemycin induces selective cytotoxicity in primary chronic lymphocytic...

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Publicado en:Oncotarget
Autores principales: Xargay-Torrent, Sílvia, López-Guerra, Mónica, Rosich, Laia, Montraveta, Arnau, Roldán, Jocabed, Rodríguez, Vanina, Villamor, Neus, Aymerich, Marta, Lagisetti, Chandraiah, Webb, Thomas R., López-Otín, Carlos, Campo, Elias, Colomer, Dolors
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673195/
https://ncbi.nlm.nih.gov/pubmed/26068951
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