The splicing modulator sudemycin induces a specific antitumor response and cooperates with ibrutinib in chronic lymphocytic leukemia

Mutations or deregulated expression of the components of the spliceosome can influence the splicing pattern of several genes and contribute to the development of tumors. In this context, we report that the spliceosome modulator sudemycin induces selective cytotoxicity in primary chronic lymphocytic...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Xargay-Torrent, Sílvia, López-Guerra, Mónica, Rosich, Laia, Montraveta, Arnau, Roldán, Jocabed, Rodríguez, Vanina, Villamor, Neus, Aymerich, Marta, Lagisetti, Chandraiah, Webb, Thomas R., López-Otín, Carlos, Campo, Elias, Colomer, Dolors
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4673195/
https://ncbi.nlm.nih.gov/pubmed/26068951
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