Increased Membrane Cholesterol Might Render Mature Hippocampal Neurons More Susceptible to β-Amyloid-Induced Calpain Activation and Tau Toxicity

by Nicholson, Alexandra M., Ferreira, Adriana
Published 2009

CHOLESTEROL AND NEURONAL SUSCEPTIBILITY TO BETA-AMYLOID TOXICITY

by Nicholson, Alexandra M., Ferreira, Adriana
Published 2010

What we know about TMEM106B in neurodegeneration

by Nicholson, Alexandra M., Rademakers, Rosa
Published in Acta Neuropathol (2016)

The TMEM106B locus and TDP-43 pathology in older persons without FTLD

by Dickson, Dennis W., Rademakers, Rosa, Nicholson, Alexandra M.
Published in Neurology (2015)

Membrane Cholesterol Modulates β-Amyloid-dependent Tau Cleavage by Inducing Changes in the Membrane Content and Localization of N-Methyl-d-aspartic Acid Receptors

by Nicholson, Alexandra M., Methner, D. Nicole Riherd, Ferreira, Adriana
Published 2011

HUMAN GENETICS AS A TOOL TO IDENTIFY PROGRANULIN REGULATORS

by Nicholson, Alexandra M., Finch, NiCole A., Rademakers, Rosa
Published 2011

Progranulin axis and recent developments in frontotemporal lobar degeneration

by Nicholson, Alexandra M, Gass, Jennifer, Petrucelli, Leonard, Rademakers, Rosa
Published 2012

β-Amyloid Carrying the Dutch Mutation Has Diverse Effects on Calpain-Mediated Toxicity in Hippocampal Neurons

by Nicholson, Alexandra M, Wold, Lindsey A, Walsh, Dominic M, Ferreira, Adriana
Published 2011

Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

by Arrant, Andrew E., Nicholson, Alexandra M., Zhou, Xiaolai, Rademakers, Rosa, Roberson, Erik D.
Published in Mol Neurodegener (2018)

Progranulin protein levels are differently regulated in plasma and CSF

by Nicholson, Alexandra M., Finch, NiCole A., Thomas, Colleen S., Wojtas, Aleksandra, Rutherford, Nicola J., Mielke, Michelle M., Roberts, Rosebud O., Boeve, Bradley F., Knopman, David S., Petersen, Ronald C., Rademakers, Rosa
Published 2014

CSF1R mutations link POLD and HDLS as a single disease entity

by Nicholson, Alexandra M., Baker, Matt C., Finch, NiCole A., Rutherford, Nicola J., Wider, Christian, Graff-Radford, Neill R., Nelson, Peter T., Clark, H. Brent, Wszolek, Zbigniew K., Dickson, Dennis W., Knopman, David S., Rademakers, Rosa
Published 2013

TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia

by Nicholson, Alexandra M., Finch, NiCole A., Wojtas, Aleksandra, Baker, Matt C., Perkerson, Ralph B., Castanedes-Casey, Monica, Rousseau, Linda, Benussi, Luisa, Binetti, Giuliano, Ghidoni, Roberta, Hsiung, Ging-Yuek R., Mackenzie, Ian R., Finger, Elizabeth, Boeve, Bradley F., Ertekin-Taner, Nilüfer, Graff-Radford, Neill R., Dickson, Dennis W., Rademakers, Rosa
Published 2013

Clinical and neuropathological features of ALS/FTD with TIA1 mutations

by Hirsch-Reinshagen, Veronica, Pottier, Cyril, Nicholson, Alexandra M., Baker, Matt, Hsiung, Ging-Yuek R., Krieger, Charles, Sengdy, Pheth, Boylan, Kevin B., Dickson, Dennis W., Mesulam, Marsel, Weintraub, Sandra, Bigio, Eileen, Zinman, Lorne, Keith, Julia, Rogaeva, Ekaterina, Zivkovic, Sasha A., Lacomis, David, Taylor, J. Paul, Rademakers, Rosa, Mackenzie, Ian R. A.
Published in Acta Neuropathol Commun (2017)

Genome-wide Screen Identifies rs646776 near Sortilin as a Regulator of Progranulin Levels in Human Plasma

by Carrasquillo, Minerva M., Nicholson, Alexandra M., Finch, NiCole, Gibbs, J. Raphael, Baker, Matt, Rutherford, Nicola J., Hunter, Talisha A., DeJesus-Hernandez, Mariely, Bisceglio, Gina D., Mackenzie, Ian R., Singleton, Andrew, Cookson, Mark R., Crook, Julia E., Dillman, Allissa, Hernandez, Dena, Petersen, Ronald C., Graff-Radford, Neill R., Younkin, Steven G., Rademakers, Rosa
Published 2010

Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies

by Zhou, Xiaolai, Nicholson, Alexandra M, Ren, Yingxue, Brooks, Mieu, Jiang, Peizhou, Zuberi, Aamir, Phuoc, Hung Nguyen, Perkerson, Ralph B, Matchett, Billie, Parsons, Tammee M, Finch, NiCole A, Lin, Wenlang, Qiao, Wenhui, Castanedes-Casey, Monica, Phillips, Virginia, Librero, Ariston L, Asmann, Yan, Bu, Guojun, Murray, Melissa E, Lutz, Cathleen, Dickson, Dennis W, Rademakers, Rosa
Published in Brain (2020)

MRI characteristics and scoring in HDLS due to CSF1R gene mutations

by Sundal, Christina, Van Gerpen, Jay A., Nicholson, Alexandra M., Wider, Christian, Shuster, Elizabeth A., Aasly, Jan, Spina, Salvatore, Ghetti, Bernardino, Roeber, Sigrun, Garbern, James, Borjesson-Hanson, Anne, Tselis, Alex, Swerdlow, Russell H., Miller, Bradley B., Fujioka, Shinsuke, Heckman, Michael G., Uitti, Ryan J., Josephs, Keith A., Baker, Matt, Andersen, Oluf, Rademakers, Rosa, Dickson, Dennis W., Broderick, Daniel, Wszolek, Zbigniew K.
Published 2012

Parkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations

by Sundal, Christina, Fujioka, Shinsuke, Van Gerpen, Jay A., Wider, Christian, Nicholson, Alexandra M., Baker, Matt, Shuster, Elizabeth A., Aasly, Jan, Spina, Salvatore, Ghetti, Bernardino, Roeber, Sigrun, Garbern, James, Tselis, Alex, Swerdlow, Russell H., Miller, Bradley B., Borjesson-Hanson, Anne, Uitti, Ryan J., Ross, Owen, Stoessl, John A., Rademakers, Rosa, Josephs, Keith A., Dickson, Dennis W., Broderick, Daniel, Wszolek, Zbigniew K.
Published 2013

Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

by Pottier, Cyril, Bieniek, Kevin F., Finch, NiCole, van de Vorst, Maartje, Baker, Matt, Perkersen, Ralph, Brown, Patricia, Ravenscroft, Thomas, van Blitterswijk, Marka, Nicholson, Alexandra M., DeTure, Michael, Knopman, David S., Josephs, Keith A., Parisi, Joseph E., Petersen, Ronald, Boylan, Kevin B., Boeve, Bradley F., Graff-Radford, Neill R., Veltman, Joris A., Gilissen, Christian, Murray, Melissa, Dicksonand, Dennis W., Rademakers, Rosa
Published in Acta Neuropathol (2015)

Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

by Nicholson, Alexandra M., Zhou, Xiaolai, Perkerson, Ralph B., Parsons, Tammee M., Chew, Jeannie, Brooks, Mieu, DeJesus-Hernandez, Mariely, Finch, NiCole A., Matchett, Billie J., Kurti, Aishe, Jansen-West, Karen R., Perkerson, Emilie, Daughrity, Lillian, Castanedes-Casey, Monica, Rousseau, Linda, Phillips, Virginia, Hu, Fenghua, Gendron, Tania F., Murray, Melissa E., Dickson, Dennis W., Fryer, John D., Petrucelli, Leonard, Rademakers, Rosa
Published in Acta Neuropathol Commun (2018)

Expanded GGGGCC hexanucleotide repeat in non-coding region of C9ORF72 causes chromosome 9p-linked frontotemporal dementia and amyotrophic lateral sclerosis

by DeJesus-Hernandez, Mariely, Mackenzie, Ian R., Boeve, Bradley F., Boxer, Adam L., Baker, Matt, Rutherford, Nicola J., Nicholson, Alexandra M., Finch, NiCole A., Gilmer, Heather Flynn, Adamson, Jennifer, Kouri, Naomi, Wojtas, Aleksandra, Sengdy, Pheth, Hsiung, Ging-Yuek R., Karydas, Anna, Seeley, William W., Josephs, Keith A., Coppola, Giovanni, Geschwind, Daniel H., Wszolek, Zbigniew K., Feldman, Howard, Knopman, David, Petersen, Ronald, Miller, Bruce L., Dickson, Dennis, Boylan, Kevin, Graff-Radford, Neill, Rademakers, Rosa
Published 2011