Chemical inhibition of wild-type p53 induced phosphatase 1 (WIP1/PPM1D) by GSK2830371 potentiates the sensitivity to MDM2 inhibitors in a p53-dependent manner

Por Esfandiari, Arman, Hawthorne, Thomas A., Nakjang, Sirintra, Lunec, John
Publicado no Mol Cancer Ther (2016)

Transport proteins of parasitic protists and their role in nutrient salvage

Por Dean, Paul, Major, Peter, Nakjang, Sirintra, Hirt, Robert P., Embley, T. Martin
Publicado em 2014

A Novel Extracellular Metallopeptidase Domain Shared by Animal Host-Associated Mutualistic and Pathogenic Microbes

Por Nakjang, Sirintra, Ndeh, Didier A., Wipat, Anil, Bolam, David N., Hirt, Robert P.
Publicado em 2012

Patterns of prokaryotic lateral gene transfers affecting parasitic microbial eukaryotes

Por Alsmark, Cecilia, Foster, Peter G, Sicheritz-Ponten, Thomas, Nakjang, Sirintra, Martin Embley, T, Hirt, Robert P
Publicado em 2013

FOXA1 regulates androgen receptor variant activity in models of castrate-resistant prostate cancer

Por Jones, Dominic, Wade, Mark, Nakjang, Sirintra, Chaytor, Lewis, Grey, James, Robson, Craig N., Gaughan, Luke
Publicado no Oncotarget (2015)

Differential regulation of the androgen receptor by protein phosphatase regulatory subunits

Por Grey, James, Jones, Dominic, Wilson, Laura, Nakjang, Sirintra, Clayton, Jake, Temperley, Richard, Clark, Emma, Gaughan, Luke, Robson, Craig
Publicado no Oncotarget (2017)

The novel anti-androgen candidate galeterone targets deubiquitinating enzymes, USP12 and USP46, to control prostate cancer growth and survival

Por McClurg, Urszula L., Azizyan, Mahsa, Dransfield, Daniel T., Namdev, Nivedita, Chit, Nay C.T.H., Nakjang, Sirintra, Robson, Craig N.
Publicado no Oncotarget (2018)

Reduction and Expansion in Microsporidian Genome Evolution: New Insights from Comparative Genomics

Por Nakjang, Sirintra, Williams, Tom A., Heinz, Eva, Watson, Andrew K., Foster, Peter G., Sendra, Kacper M., Heaps, Sarah E., Hirt, Robert P., Martin Embley, T.
Publicado em 2013

A Recent Whole-Genome Duplication Divides Populations of a Globally Distributed Microsporidian

Por Williams, Tom A., Nakjang, Sirintra, Campbell, Scott E., Freeman, Mark A., Eydal, Matthías, Moore, Karen, Hirt, Robert P., Embley, T. Martin, Williams, Bryony A. P.
Publicado no Mol Biol Evol (2016)

Development and exploitation of a novel mutant androgen receptor modelling strategy to identify new targets for advanced prostate cancer therapy

Por O'Neill, Daniel, Jones, Dominic, Wade, Mark, Grey, James, Nakjang, Sirintra, Guo, Wenrui, Cork, David, Davies, Barry R., Wedge, Steve R., Robson, Craig N., Gaughan, Luke
Publicado no Oncotarget (2015)

Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity

Por McClurg, Urszula L., Cork, David M.W., Darby, Steven, Ryan-Munden, Claudia A., Nakjang, Sirintra, Mendes Côrtes, Leticia, Treumann, Achim, Gaughan, Luke, Robson, Craig N.
Publicado no Nucleic Acids Res (2017)

Transporter gene acquisition and innovation in the evolution of Microsporidia intracellular parasites

Por Dean, P., Sendra, K. M., Williams, T. A., Watson, A. K., Major, P., Nakjang, S., Kozhevnikova, E., Goldberg, A. V., Kunji, E. R. S., Hirt, R. P., Embley, T. M.
Publicado no Nat Commun (2018)

Plasma Membrane-Located Purine Nucleotide Transport Proteins Are Key Components for Host Exploitation by Microsporidian Intracellular Parasites

Por Heinz, Eva, Hacker, Christian, Dean, Paul, Mifsud, John, Goldberg, Alina V., Williams, Tom A., Nakjang, Sirintra, Gregory, Alison, Hirt, Robert P., Lucocq, John M., Kunji, Edmund R. S., Embley, T. Martin
Publicado no PLoS Pathog (2014)

Evolutionary conservation and in vitro reconstitution of microsporidian iron–sulfur cluster biosynthesis

Por Freibert, Sven-A., Goldberg, Alina V., Hacker, Christian, Molik, Sabine, Dean, Paul, Williams, Tom A., Nakjang, Sirintra, Long, Shaojun, Sendra, Kacper, Bill, Eckhard, Heinz, Eva, Hirt, Robert P., Lucocq, John M, Embley, T. Martin, Lill, Roland
Publicado no Nat Commun (2017)

Characterisation of the genomic landscape of CRLF2‐rearranged acute lymphoblastic leukemia

Por Russell, Lisa J., Jones, Lisa, Enshaei, Amir, Tonin, Stefano, Ryan, Sarra L., Eswaran, Jeyanthy, Nakjang, Sirintra, Papaemmanuil, Elli, Tubio, Jose M. C., Fielding, Adele K., Vora, Ajay, Campbell, Peter J., Moorman, Anthony V., Harrison, Christine J.
Publicado no Genes Chromosomes Cancer (2017)

MEDU-06. NOVEL MOLECULAR SUBGROUPS IMPROVE CLINICAL CLASSIFICATION AND OUTCOME PREDICTION FOR CHILDHOOD MEDULLOBLASTOMA

Por Schwalbe, Edward, Lindsey, Janet, Nakjang, Sirintra, Crosier, Stephen, Smith, Amanda, Hicks, Debbie, Rafiee, Gholamreza, Hill, Rebecca, Iliasova, Alice, Stone, Thomas, Pizer, Barry, Michalski, Anthony, Joshi, Abhijit, Robson, Keith, Wharton, Stephen, Jacques, Thomas, Bailey, Simon, Williamson, Daniel, Clifford, Steven
Publicado no Neuro Oncol (2017)

Inhibition of monocarboxyate transporter 1 by AZD3965 as a novel therapeutic approach for diffuse large B-cell lymphoma and Burkitt lymphoma

Por Noble, Richard A., Bell, Natalie, Blair, Helen, Sikka, Arti, Thomas, Huw, Phillips, Nicole, Nakjang, Sirintra, Miwa, Satomi, Crossland, Rachel, Rand, Vikki, Televantou, Despina, Long, Anna, Keun, Hector C., Bacon, Chris M., Bomken, Simon, Critchlow, Susan E., Wedge, Stephen R.
Publicado no Haematologica (2017)

Epigenetic landscape correlates with genetic subtype but does not predict outcome in childhood acute lymphoblastic leukemia

Por Gabriel, Alem S, Lafta, Fadhel M, Schwalbe, Edward C, Nakjang, Sirintra, Cockell, Simon J, Iliasova, Alice, Enshaei, Amir, Schwab, Claire, Rand, Vikki, Clifford, Steven C, Kinsey, Sally E, Mitchell, Chris D, Vora, Ajay, Harrison, Christine J, Moorman, Anthony V, Strathdee, Gordon
Publicado no Epigenetics (2015)

AT-20 INTEGRATED PATHWAY ANALYSIS OF RHABDOID TUMOR SUBTYPES IDENTIFIES KEY SMARCB1-DEPENDENCIES AND THERAPEUTIC OPPORTUNITIES

Por Finetti, Martina A., Del Carpio-Pons, Alicia, Wong, Jocelyn P., Batting, Sarah, Barker, James, Wood, James, Nakjang, Sirintra, Crosier, Stephen, Smith, Amanda, Selby, Matthew P., Ramli, Ras A., Grabovska, Yura, Treumann, Achim, Huang, Paul H., Bailey, Simon, Clifford, Steven C., Williamson, Daniel
Publicado no Neuro Oncol (2016)

Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study

Por Schwalbe, Edward C, Lindsey, Janet C, Nakjang, Sirintra, Crosier, Stephen, Smith, Amanda J, Hicks, Debbie, Rafiee, Gholamreza, Hill, Rebecca M, Iliasova, Alice, Stone, Thomas, Pizer, Barry, Michalski, Antony, Joshi, Abhijit, Wharton, Stephen B, Jacques, Thomas S, Bailey, Simon, Williamson, Daniel, Clifford, Steven C
Publicado no Lancet Oncol (2017)