Identification of a novel K311 ubiquitination site critical for androgen receptor transcriptional activity

The androgen receptor (AR) is the main driver of prostate cancer (PC) development and progression, and the primary therapeutic target in PC. To date, two functional ubiquitination sites have been identified on AR, both located in its C-terminal ligand binding domain (LBD). Recent reports highlight t...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: McClurg, Urszula L., Cork, David M.W., Darby, Steven, Ryan-Munden, Claudia A., Nakjang, Sirintra, Mendes Côrtes, Leticia, Treumann, Achim, Gaughan, Luke, Robson, Craig N.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5389688/
https://ncbi.nlm.nih.gov/pubmed/27903893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw1162
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