Laddar...
Chemical inhibition of wild-type p53 induced phosphatase 1 (WIP1/PPM1D) by GSK2830371 potentiates the sensitivity to MDM2 inhibitors in a p53-dependent manner
Sensitivity to MDM2 inhibitors is widely different among responsive TP53 wild-type cell lines and tumours. Understanding the determinants of MDM2 inhibitor sensitivity is pertinent for their optimal clinical application. Wild-type p53-inducible phosphatase-1 (WIP1) encoded by PPM1D, is activated, ga...
Sparad:
| I publikationen: | Mol Cancer Ther |
|---|---|
| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
2016
|
| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4785723/ https://ncbi.nlm.nih.gov/pubmed/26832796 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-15-0651 |
| Taggar: |
Lägg till en tagg
Inga taggar, Lägg till första taggen!
|