Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

The DNA damage response (DDR) pathway and its core component tumor suppressor p53 block cell cycle progression after genotoxic stress and represent an intrinsic barrier preventing cancer development. The serine/threonine phosphatase PPM1D/Wip1 inactivates p53 and promotes termination of the DDR path...

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Main Authors: Kleiblova, Petra, Shaltiel, Indra A., Benada, Jan, Ševčík, Jan, Pecháčková, Soňa, Pohlreich, Petr, Voest, Emile E., Dundr, Pavel, Bartek, Jiri, Kleibl, Zdenek, Medema, René H., Macurek, Libor
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2013
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653305/
https://ncbi.nlm.nih.gov/pubmed/23649806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201210031
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