Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint

The DNA damage response (DDR) pathway and its core component tumor suppressor p53 block cell cycle progression after genotoxic stress and represent an intrinsic barrier preventing cancer development. The serine/threonine phosphatase PPM1D/Wip1 inactivates p53 and promotes termination of the DDR path...

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Autores principales: Kleiblova, Petra, Shaltiel, Indra A., Benada, Jan, Ševčík, Jan, Pecháčková, Soňa, Pohlreich, Petr, Voest, Emile E., Dundr, Pavel, Bartek, Jiri, Kleibl, Zdenek, Medema, René H., Macurek, Libor
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653305/
https://ncbi.nlm.nih.gov/pubmed/23649806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201210031
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