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ATM/Wip1 activities at chromatin control Plk1 re‐activation to determine G2 checkpoint duration
After DNA damage, the cell cycle is arrested to avoid propagation of mutations. Arrest in G2 phase is initiated by ATM‐/ATR‐dependent signaling that inhibits mitosis‐promoting kinases such as Plk1. At the same time, Plk1 can counteract ATR‐dependent signaling and is required for eventual resumption...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5510006/ https://ncbi.nlm.nih.gov/pubmed/28607002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201696082 |
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