Spatial Separation of Plk1 Phosphorylation and Activity

Polo-like kinase 1 (Plk1) is one of the major kinases controlling mitosis and cell division. Plk1 is first recruited to the centrosome in S phase, then appears on the kinetochores in late G2, and at the end of mitosis, it translocates to the central spindle. Activation of Plk1 requires phosphorylati...

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Bibliografiska uppgifter
I publikationen:Front Oncol
Huvudupphovsmän: Bruinsma, Wytse, Aprelia, Melinda, Kool, Jolanda, Macurek, Libor, Lindqvist, Arne, Medema, René H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2015
Ämnen:
Oncology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4462105/
https://ncbi.nlm.nih.gov/pubmed/26114094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2015.00132
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