Phosphorylation-mediated stabilization of Bora in mitosis coordinates Plx1/Plk1 and Cdk1 oscillations

Cdk1 and Plk1/Plx1 activation leads to their inactivation through negative feedback loops. Cdk1 deactivates itself by activating the APC/C, consequently generating embryonic cell cycle oscillations. APC/C inhibition by the mitotic checkpoint in somatic cells and the cytostatic factor (CSF) in oocyte...

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Autors principals: Feine, Oren, Hukasova, Elvira, Bruinsma, Wytse, Freire, Raimundo, Fainsod, Abraham, Gannon, Julian, Mahbubani, Hiro M, Lindqvist, Arne, Brandeis, Michael
Format: Artigo
Idioma:Inglês
Publicat: Landes Bioscience 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4111719/
https://ncbi.nlm.nih.gov/pubmed/24675888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.28630
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