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DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation
To maintain genome stability, cells need to replicate their DNA before dividing. Upon completion of bulk DNA synthesis, the mitotic kinases CDK1 and PLK1 become active and drive entry into mitosis. Here, we have tested the hypothesis that DNA replication determines the timing of mitotic kinase activ...
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| Publicado no: | Mol Cell |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cell Press
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6039720/ https://ncbi.nlm.nih.gov/pubmed/30008317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.05.026 |
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