DNA Replication Determines Timing of Mitosis by Restricting CDK1 and PLK1 Activation

To maintain genome stability, cells need to replicate their DNA before dividing. Upon completion of bulk DNA synthesis, the mitotic kinases CDK1 and PLK1 become active and drive entry into mitosis. Here, we have tested the hypothesis that DNA replication determines the timing of mitotic kinase activ...

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Pubblicato in:Mol Cell
Autori principali: Lemmens, Bennie, Hegarat, Nadia, Akopyan, Karen, Sala-Gaston, Joan, Bartek, Jiri, Hochegger, Helfrid, Lindqvist, Arne
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039720/
https://ncbi.nlm.nih.gov/pubmed/30008317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.05.026
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