Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

Cyclin-dependent kinase 1 (Cdk1) is thought to trigger centrosome separation in late G2 phase by phosphorylating the motor protein Eg5 at Thr927. However, the precise control mechanism of centrosome separation remains to be understood. Here, we report that in G2 phase polo-like kinase 1 (Plk1) can t...

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Main Authors: Smith, Ewan, Hégarat, Nadia, Vesely, Clare, Roseboom, Isaac, Larch, Chris, Streicher, Hansjörg, Straatman, Kornelis, Flynn, Helen, Skehel, Mark, Hirota, Toru, Kuriyama, Ryoko, Hochegger, Helfrid
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117641/
https://ncbi.nlm.nih.gov/pubmed/21522128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.120
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