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Centrosome Amplification in CHO and DT40 Cells by Inactivation of Cyclin-dependent Kinases

To study the mechanism of centrosome duplication in cycling cells, we established a novel system of multiple centrosome formation in two types of cells: CHO cells treated with a cdk1 inhibitor (RO3306) and DT40 cells, in which Cyclin-dependent kinases (Cdks) were knocked out by chemical genetics. Cd...

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Detalhes bibliográficos
Main Authors: Steere, Nathan, Wagner, Michael, Beishir, Stephen, Smith, Ewan, Breslin, Loretta, Morrison, Ciaran G., Hochegger, Helfrid, Kuriyama, Ryoko
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3166434/
https://ncbi.nlm.nih.gov/pubmed/21766470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cm.20523
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