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Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6/7 and Eg5
The NIMA-family kinases Nek9/Nercc1, Nek6 and Nek7 form a signalling module required for mitotic spindle assembly. Nek9, the upstream kinase, is activated during prophase at centrosomes although the details of this have remained elusive. We now identify Plk1 as Nek9 direct activator and propose a tw...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3155310/ https://ncbi.nlm.nih.gov/pubmed/21642957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.179 |
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