Wip1 confers G2 checkpoint recovery competence by counteracting p53-dependent transcriptional repression

Activation of the DNA damage checkpoint causes a cell-cycle arrest through inhibition of cyclin-dependent kinases (cdks). To successfully recover from the arrest, a cell should somehow be maintained in its proper cell-cycle phase. This problem is particularly eminent when a cell arrests in G2, as cd...

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Main Authors: Lindqvist, Arne, de Bruijn, Menno, Macurek, Libor, Brás, Alexandra, Mensinga, Anneloes, Bruinsma, Wytse, Voets, Olaf, Kranenburg, Onno, Medema, René H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2771084/
https://ncbi.nlm.nih.gov/pubmed/19713933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.246
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