Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis

Cells are constantly challenged by DNA damage and protect their genome integrity by activation of an evolutionary conserved DNA damage response pathway (DDR). A central core of DDR is composed of a spatiotemporally ordered net of post-translational modifications, among which protein phosphorylation...

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Main Authors: Macurek, Libor, Benada, Jan, Müllers, Erik, Halim, Vincentius A., Krejčíková, Kateřina, Burdová, Kamila, Pecháčková, Sona, Hodný, Zdeněk, Lindqvist, Arne, Medema, René H., Bartek, Jiri
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3575454/
https://ncbi.nlm.nih.gov/pubmed/23255129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23057
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