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Residual Cdk1/2 activity after DNA damage promotes senescence
In response to DNA damage, a cell can be forced to permanently exit the cell cycle and become senescent. Senescence provides an early barrier against tumor development by preventing proliferation of cells with damaged DNA. By studying single cells, we show that Cdk activity persists after DNA damage...
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| Publicado no: | Aging Cell |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5418196/ https://ncbi.nlm.nih.gov/pubmed/28345297 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12588 |
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