Wip1 inhibitor GSK2830371 inhibits neuroblastoma growth by inducing Chk2/p53-mediated apoptosis

Neuroblastoma (NB) is the most common extracranial tumor in children. Unlike in most adult tumors, tumor suppressor protein 53 (p53) mutations occur with a relatively low frequency in NB and the downstream function of p53 is intact in NB cell lines. Wip1 is a negative regulator of p53 and hindrance...

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Pubblicato in:Sci Rep
Autori principali: Chen, Zhenghu, Wang, Long, Yao, Dayong, Yang, Tianshu, Cao, Wen-Ming, Dou, Jun, Pang, Jonathan C., Guan, Shan, Zhang, Huiyuan, Yu, Yang, Zhao, Yanling, Wang, Yongfeng, Xu, Xin, Shi, Yan, Patel, Roma, Zhang, Hong, Vasudevan, Sanjeev A., Liu, Shangfeng, Yang, Jianhua, Nuchtern, Jed G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5171816/
https://ncbi.nlm.nih.gov/pubmed/27991505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38011
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