mTOR ATP-competitive inhibitor INK128 inhibits neuroblastoma growth via blocking mTORC signaling

High-risk neuroblastoma often develops resistance to high-dose chemotherapy. The mTOR signaling cascade is frequently deregulated in human cancers and targeting mTOR signaling sensitizes many cancer types to chemotherapy. Here, using a panel of neuroblastoma cell lines, we found that the mTOR inhibi...

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Bibliografske podrobnosti
izdano v:Apoptosis
Main Authors: Zhang, Huiyuan, Dou, Jun, Yu, Yang, Zhao, Yanling, Fan, Yihui, Cheng, Jin, Xu, Xin, Liu, Wei, Guan, Shan, Chen, Zhenghu, shi, Yan, Patel, Roma, Vasudevan, Sanjeev A, Zage, Peter E, Zhang, Hong, Nuchtern, Jed G, Kim, Eugene S, Fu, Songbin, Yang, Jianhua
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4593396/
https://ncbi.nlm.nih.gov/pubmed/25425103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-014-1066-0
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