The preclinical evaluation of the dual mTORC1/2 inhibitor INK-128 as a potential anti-colorectal cancer agent

The colorectal cancer is the leading contributor of cancer-related mortality. Mammalian target of rapamycin (mTOR), existing in 2 complexes (mTORC1/2), is frequently dysregulated and constitutively activated in colorectal cancers. It represents an important drug target. Here we found that INK-128, t...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Li, Chen, Cui, Jian-Feng, Chen, Min-Bin, Liu, Chao-Ying, Liu, Feng, Zhang, Qian-De, Zou, Jian, Lu, Pei-Hua
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4623257/
https://ncbi.nlm.nih.gov/pubmed/25692620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384047.2014.972274
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https://ncbi.nlm.nih.gov/pmc/articles/PMC4623257/
https://ncbi.nlm.nih.gov/pubmed/25692620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384047.2014.972274

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