Application of structural-dynamic approaches provide novel insights into the enzymatic mechanism of the tumor necrosis factor-α converting enzyme (TACE)

Por Sagi, Irit, Milla, Marcos E.
Publicado em 2007

Chaperone-like properties of the prodomain of TNFα-converting enzyme (TACE) and the functional role of its cysteine switch

Por Leonard, Jennifer D., Lin, Frank, Milla, Marcos E.
Publicado em 2005

Key feature of the catalytic cycle of TNF-α converting enzyme involves communication between distal protein sites and the enzyme catalytic core

Por Solomon, Ariel, Akabayov, Barak, Frenkel, Anatoly, Milla, Marcos E., Sagi, Irit
Publicado em 2007

Phenotypic Approaches to Identify Inhibitors of B Cell Activation

Por Rex, Elizabeth B., Kim, Suzie, Wiener, Jake, Rao, Navin L., Milla, Marcos E., DiSepio, Daniel
Publicado no J Biomol Screen (2015)

Effects of TNFα-Converting Enzyme Inhibition on Amyloid β Production and APP Processing In Vitro and In Vivo

Por Kim, Minkyu L., Zhang, Bin, Mills, Ian P., Milla, Marcos E., Brunden, Kurt R., Lee, Virginia M.-Y.
Publicado em 2008

Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo

Por Wong, Eitan, Cohen, Tal, Romi, Erez, Levin, Maxim, Peleg, Yoav, Arad, Uri, Yaron, Avraham, Milla, Marcos E., Sagi, Irit
Publicado no Sci Rep (2016)

Molecular analysis of model gut microbiotas by imaging mass spectrometry and nano-desorption electrospray ionization reveals dietary metabolite transformations

Por Rath, Christopher M., Alexandrov, Theodore, Higginbottom, Steven K., Song, Jiao, Milla, Marcos, Fischbach, Michael, Sonnenburg, Justin L., Dorrestein, Pieter C.
Publicado em 2012

Phenotyping drug polypharmacology via eicosanoid profiling of blood

Por Song, Jiao, Liu, Xuejun, Rao, Tadimeti S., Chang, Leon, Meehan, Michael J., Blevitt, Jonathan M., Wu, Jiejun, Dorrestein, Pieter C., Milla, Marcos E.
Publicado no J Lipid Res (2015)

A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors

Por Blevitt, Jonathan M., Hack, Michael D., Herman, Krystal, Chang, Leon, Keith, John M., Mirzadegan, Tara, Rao, Navin L., Lebsack, Alec D., Milla, Marcos E.
Publicado no J Biol Chem (2016)

AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist

Por Gever, Joel R, Soto, Rothschild, Henningsen, Robert A, Martin, Renee S, Hackos, David H, Panicker, Sandip, Rubas, Werner, Oglesby, Ian B, Dillon, Michael P, Milla, Marcos E, Burnstock, Geoffrey, Ford, Anthony PDW
Publicado em 2010

Isoproterenol Acts as a Biased Agonist of the Alpha-1A-Adrenoceptor that Selectively Activates the MAPK/ERK Pathway

Por Copik, Alicja. J., Baldys, Aleksander, Nguyen, Khanh, Sahdeo, Sunil, Ho, Hoangdung, Kosaka, Alan, Dietrich, Paul J., Fitch, Bill, Raymond, John R., Ford, Anthony P. D. W., Button, Donald, Milla, Marcos E.
Publicado no PLoS One (2015)

Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury

Por Zhu, Li, Bergmeier, Wolfgang, Wu, Jie, Jiang, Hong, Stalker, Timothy J., Cieslak, Marcin, Fan, Ran, Boumsell, Laurence, Kumanogoh, Atsushi, Kikutani, Hitoshi, Tamagnone, Luca, Wagner, Denisa D., Milla, Marcos E., Brass, Lawrence F.
Publicado em 2007

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation

Por Soroosh, Pejman, Wu, Jiejun, Xue, Xiaohua, Song, Jiao, Sutton, Steven W., Sablad, Marciano, Yu, Jingxue, Nelen, Marina I., Liu, Xuejun, Castro, Glenda, Luna, Rosa, Crawford, Shelby, Banie, Homayon, Dandridge, Rose A., Deng, Xiaohu, Bittner, Anton, Kuei, Chester, Tootoonchi, Mandana, Rozenkrants, Natasha, Herman, Krystal, Gao, Jingjin, Yang, Xia V., Sachen, Kacey, Ngo, Karen, Fung-Leung, Wai-Ping, Nguyen, Steven, de Leon-Tabaldo, Aimee, Blevitt, Jonathan, Zhang, Yan, Cummings, Maxwell D., Rao, Tadimeti, Mani, Neelakandha S., Liu, Changlu, McKinnon, Murray, Milla, Marcos E., Fourie, Anne M., Sun, Siquan
Publicado em 2014