A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors

5-Lipoxygenase activating protein (FLAP) plays a critical role in the metabolism of arachidonic acid to leukotriene A(4), the precursor to the potent pro-inflammatory mediators leukotriene B(4) and leukotriene C(4). Studies with small molecule inhibitors of FLAP have led to the discovery of a drug b...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Blevitt, Jonathan M., Hack, Michael D., Herman, Krystal, Chang, Leon, Keith, John M., Mirzadegan, Tara, Rao, Navin L., Lebsack, Alec D., Milla, Marcos E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2016
Onderwerpen:
Membrane Biology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4933458/
https://ncbi.nlm.nih.gov/pubmed/27129215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.725325
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