Phenotyping drug polypharmacology via eicosanoid profiling of blood

It is widely accepted that small-molecule drugs, despite their selectivity at primary targets, exert pharmacological effects (and safety liabilities) through a multiplicity of pathways. As such, it has proved extremely difficult to experimentally assess polypharmacology in an agnostic fashion. Profi...

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Vydáno v:J Lipid Res
Hlavní autoři: Song, Jiao, Liu, Xuejun, Rao, Tadimeti S., Chang, Leon, Meehan, Michael J., Blevitt, Jonathan M., Wu, Jiejun, Dorrestein, Pieter C., Milla, Marcos E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2015
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4513990/
https://ncbi.nlm.nih.gov/pubmed/26022804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M058677
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