Leveraging systems biology approaches in clinical pharmacology

od Melas, Ioannis N, Kretsos, Kosmas, Alexopoulos, Leonidas G
Izdano 2013

Identification of signaling pathways related to drug efficacy in hepatocellular carcinoma via integration of phosphoproteomic, genomic and clinical data

od Melas, Ioannis N., Lauffenburger, Douglas A., Alexopoulos, Leonidas G.
izdano v Proc IEEE Int Symp Bioinformatics Bioeng (2013)

Detecting and Removing Inconsistencies between Experimental Data and Signaling Network Topologies Using Integer Linear Programming on Interaction Graphs

od Melas, Ioannis N., Samaga, Regina, Alexopoulos, Leonidas G., Klamt, Steffen
Izdano 2013

Network Reconstruction Based on Proteomic Data and Prior Knowledge of Protein Connectivity Using Graph Theory

od Stavrakas, Vassilis, Melas, Ioannis N., Sakellaropoulos, Theodore, Alexopoulos, Leonidas G.
izdano v PLoS One (2015)

Combined logical and data-driven models for linking signalling pathways to cellular response

od Melas, Ioannis N, Mitsos, Alexander, Messinis, Dimitris E, Weiss, Thomas S, Alexopoulos, Leonidas G
Izdano 2011

Identifying Drug Effects via Pathway Alterations using an Integer Linear Programming Optimization Formulation on Phosphoproteomic Data

od Mitsos, Alexander, Melas, Ioannis N., Siminelakis, Paraskeuas, Chairakaki, Aikaterini D., Saez-Rodriguez, Julio, Alexopoulos, Leonidas G.
Izdano 2009

Non Linear Programming (NLP) Formulation for Quantitative Modeling of Protein Signal Transduction Pathways

od Mitsos, Alexander, Melas, Ioannis N., Morris, Melody K., Saez-Rodriguez, Julio, Lauffenburger, Douglas A., Alexopoulos, Leonidas G.
Izdano 2012

Translational systems pharmacology‐based predictive assessment of drug‐induced cardiomyopathy

od Messinis, Dimitris E., Melas, Ioannis N., Hur, Junguk, Varshney, Navya, Alexopoulos, Leonidas G., Bai, Jane P.F.
izdano v CPT Pharmacometrics Syst Pharmacol (2018)

A crowd-sourcing approach for the construction of species-specific cell signaling networks

od Bilal, Erhan, Sakellaropoulos, Theodore, Participants, Challenge, Melas, Ioannis N., Messinis, Dimitris E., Belcastro, Vincenzo, Rhrissorrakrai, Kahn, Meyer, Pablo, Norel, Raquel, Iskandar, Anita, Blaese, Elise, Rice, John J., Peitsch, Manuel C., Hoeng, Julia, Stolovitzky, Gustavo, Alexopoulos, Leonidas G., Poussin, Carine
izdano v Bioinformatics (2015)

The species translation challenge—A systems biology perspective on human and rat bronchial epithelial cells

od Poussin, Carine, Mathis, Carole, Alexopoulos, Leonidas G, Messinis, Dimitris E, Dulize, Rémi H J, Belcastro, Vincenzo, Melas, Ioannis N, Sakellaropoulos, Theodore, Rhrissorrakrai, Kahn, Bilal, Erhan, Meyer, Pablo, Talikka, Marja, Boué, Stéphanie, Norel, Raquel, Rice, John J, Stolovitzky, Gustavo, Ivanov, Nikolai V, Peitsch, Manuel C, Hoeng, Julia
izdano v Sci Data (2014)