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Identification of signaling pathways related to drug efficacy in hepatocellular carcinoma via integration of phosphoproteomic, genomic and clinical data

Hepatocellular Carcinoma (HCC) is one of the leading causes of death worldwide, with only a handful of treatments effective in unresectable HCC. Most of the clinical trials for HCC using new generation interventions (drug-targeted therapies) have poor efficacy whereas just a few of them show some pr...

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Bibliographic Details
Published in:Proc IEEE Int Symp Bioinformatics Bioeng
Main Authors: Melas, Ioannis N., Lauffenburger, Douglas A., Alexopoulos, Leonidas G.
Format: Artigo
Language:Inglês
Published: 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340693/
https://ncbi.nlm.nih.gov/pubmed/25729777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1109/BIBE.2013.6701683
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