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A multipathway phosphoproteomic signaling network model of idiosyncratic drug- and inflammatory cytokine-induced toxicity in human hepatocytes
Idiosyncratic drug hepatotoxicity is a hepatotoxicity subset that occurs in a very small fraction of human patients, is poorly predicted by standard preclinical models and in clinical trials, and frequently leads to post-approval drug failure. Animal models utilizing bacterial LPS co-administration...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3998841/ https://ncbi.nlm.nih.gov/pubmed/19964679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1109/IEMBS.2009.5334019 |
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