The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

Por Melander, Roberta J., Melander, Christian
Publicado no ACS Infect Dis (2017)

Controlling bacterial behavior with indole-containing natural products and derivatives

Por Melander, Roberta J., Minvielle, Marine J., Melander, Christian
Publicado em 2014

Narrow-spectrum antibacterial agents

Por Melander, Roberta J., Zurawski, Daniel V., Melander, Christian
Publicado no Medchemcomm (2017)

Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors

Por Wright, Christopher J., Wu, Hui, Melander, Roberta J., Melander, Christian, Lamont, Richard J.
Publicado em 2014

Marine sponge alkaloids as a source of anti-bacterial adjuvants

Por Melander, Roberta J., Liu, Hong-bing, Stephens, Matthew D., Bewley, Carole A., Melander, Christian
Publicado no Bioorg Med Chem Lett (2016)

Meridianin D Analogues Display Antibiofilm Activity against MRSA and Increase Colistin Efficacy in Gram-Negative Bacteria

Por Huggins, William M., Barker, William T., Baker, James T., Hahn, Nicholas A., Melander, Roberta J., Melander, Christian
Publicado no ACS Med Chem Lett (2018)

Reversal of Mycobacterium tuberculosis Phenotypic Drug Resistance by 2-Aminoimidazole Based Small Molecules

Por Ackart, David F., Lindsey, Erick A., Podell, Brendan K., Melander, Roberta J., Basaraba, Randall J., Melander, Christian
Publicado no Pathog Dis (2014)

Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered through Small Molecule Variable Ligand Display

Por Byrne-Nash, Rose, Lucero, Danielle M., Osbaugh, Niki A., Melander, Roberta J., Melander, Christian, Feldheim, Daniel L.
Publicado no Bioconjug Chem (2017)

A Bifurcated Proteoglycan Binding Small Molecule Carrier for siRNA Delivery

Por Gooding, Matt, Adigbli, Derick, Edith Chan, A W, Melander, Roberta J, MacRobert, Alexander J, Selwood, David L
Publicado no Chem Biol Drug Des (2014)

Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis

Por Gifford, Jennifer C., Bresee, Jamee, Carter, Carly Jo, Wang, Guankui, Melander, Roberta J., Melander, Christian, Feldheim, Daniel L.
Publicado no Chem Commun (Camb) (2014)

Potentiation of Francisella Resistance to Conventional Antibiotics through Small Molecule Adjuvants

Por Stephens, Matthew D., Hubble, Veroncia B., Ernst, Robert K., van Hoek, Monique L., Melander, Roberta J., Cavanagh, John, Melander, Christian
Publicado no Medchemcomm (2015)

Second Generation Modifiers of Colistin Resistance Show Enhanced Activity and Lower Inherent Toxicity

Por Brackett, Christopher M., Furlani, Robert E., Anderson, Ryan G., Krishnamurthy, Aparna, Melander, Roberta J., Moskowitz, Samuel M., Ernst, Robert K., Melander, Christian
Publicado no Tetrahedron (2016)

Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives

Por Richardson, Mike A., Furlani, Robert E., Podell, Brendan K., Ackart, David F., Haugen, Jessica D., Melander, Roberta J., Melander, Christian, Basaraba, Randall J.
Publicado no Tetrahedron Lett (2015)

Second Generation 2-Aminoimidazole Based Advanced Glycation End Product Inhibitors and Breakers

Por Furlani, Robert E., Richardson, Mike A., Podell, Brendan K., Ackart, David F., Haugen, Jessica D., Melander, Roberta J., Basaraba, Randall J., Melande, Christian
Publicado no Bioorg Med Chem Lett (2015)

1,2,4-Triazolidine-3-thiones as Narrow Spectrum Antibiotics against Multidrug-Resistant Acinetobacter baumannii

Por Huggins, William M., Minrovic, Bradley M., Corey, Brendan W., Jacobs, Anna C., Melander, Roberta J., Sommer, Roger D., Zurawski, Daniel V., Melander, Christian
Publicado no ACS Med Chem Lett (2016)

Small Molecule Adjuvants that Suppress Both Chromosomal and mcr-1 Encoded Colistin-Resistance and Amplify Colistin Efficacy in Polymyxin-Susceptible Bacteria

Por Barker, William T., Martin, Sara E., Chandler, Courtney E., Nguyen, T. Vu, Harris, Tyler L., Goodell, Christopher, Melander, Roberta J., Doi, Yohei, Ernst, Robert K., Melander, Christian
Publicado no Bioorg Med Chem (2017)

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and...

Por Milton, Morgan E., Minrovic, Bradley M., Harris, Danni L., Kang, Brian, Jung, David, Lewis, Caleb P., Thompson, Richele J., Melander, Roberta J., Zeng, Daina, Melander, Christian, Cavanagh, John
Publicado no Front Mol Biosci (2018)

1,2,4-Triazolidine-3-thiones Have Specific Activity against Acinetobacter baumannii among Common Nosocomial Pathogens

Por Corey, Brendan W., Thompson, Mitchell G., Hittle, Lauren E., Jacobs, Anna C., Asafo-Adjei, Edward A., Huggins, William M., Melander, Roberta J., Melander, Christian, Ernst, Robert K., Zurawski, Daniel V.
Publicado no ACS Infect Dis (2016)

Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds

Por Milton, Morgan E., Allen, C. Leigh, Feldmann, Erik A., Bobay, Benjamin G., Jung, David K., Stephens, Matthew D., Melander, Roberta J., Theisen, Kelly E., Zeng, Daina, Thompson, Richele J., Melander, Christian, Cavanagh, John
Publicado no Mol Microbiol (2017)

2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability

Por Jeon, Albert B., Obregón-Henao, Andrés, Ackart, David F., Podell, Brendan K., Belardinelli, Juan M., Jackson, Mary, Nguyen, Tuan V., Blackledge, Meghan S., Melander, Roberta J., Melander, Christian, Johnson, Benjamin K., Abramovitch, Robert B., Basaraba, Randall J.
Publicado no PLoS One (2017)