2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability

There is an urgent need to develop new drug treatment strategies to control the global spread of drug-sensitive and multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis). The ß-lactam class of antibiotics is among the safest and most widely prescribed antibiotics, but they are not effecti...

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Publicado en:PLoS One
Autores principales: Jeon, Albert B., Obregón-Henao, Andrés, Ackart, David F., Podell, Brendan K., Belardinelli, Juan M., Jackson, Mary, Nguyen, Tuan V., Blackledge, Meghan S., Melander, Roberta J., Melander, Christian, Johnson, Benjamin K., Abramovitch, Robert B., Basaraba, Randall J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547695/
https://ncbi.nlm.nih.gov/pubmed/28749949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180925
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