2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability

There is an urgent need to develop new drug treatment strategies to control the global spread of drug-sensitive and multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis). The ß-lactam class of antibiotics is among the safest and most widely prescribed antibiotics, but they are not effecti...

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Vydáno v:PLoS One
Hlavní autoři: Jeon, Albert B., Obregón-Henao, Andrés, Ackart, David F., Podell, Brendan K., Belardinelli, Juan M., Jackson, Mary, Nguyen, Tuan V., Blackledge, Meghan S., Melander, Roberta J., Melander, Christian, Johnson, Benjamin K., Abramovitch, Robert B., Basaraba, Randall J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547695/
https://ncbi.nlm.nih.gov/pubmed/28749949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180925
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