2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain

There is an urgent need to develop new drugs against tuberculosis. In particular, it is critical to target drug tolerant Mycobacterium tuberculosis (M. tuberculosis), responsible, in part, for the lengthy antibiotic regimen required for treatment. We previously postulated that the presence of in viv...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jeon, Albert Byungyun, Ackart, David F., Li, Wei, Jackson, Mary, Melander, Roberta J., Melander, Christian, Abramovitch, Robert B., Chicco, Adam J., Basaraba, Randall J., Obregón-Henao, Andrés
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365497/
https://ncbi.nlm.nih.gov/pubmed/30728417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-38064-7
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