2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability

There is an urgent need to develop new drug treatment strategies to control the global spread of drug-sensitive and multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis). The ß-lactam class of antibiotics is among the safest and most widely prescribed antibiotics, but they are not effecti...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Jeon, Albert B., Obregón-Henao, Andrés, Ackart, David F., Podell, Brendan K., Belardinelli, Juan M., Jackson, Mary, Nguyen, Tuan V., Blackledge, Meghan S., Melander, Roberta J., Melander, Christian, Johnson, Benjamin K., Abramovitch, Robert B., Basaraba, Randall J.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547695/
https://ncbi.nlm.nih.gov/pubmed/28749949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180925
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