2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability

There is an urgent need to develop new drug treatment strategies to control the global spread of drug-sensitive and multidrug-resistant Mycobacterium tuberculosis (M. tuberculosis). The ß-lactam class of antibiotics is among the safest and most widely prescribed antibiotics, but they are not effecti...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jeon, Albert B., Obregón-Henao, Andrés, Ackart, David F., Podell, Brendan K., Belardinelli, Juan M., Jackson, Mary, Nguyen, Tuan V., Blackledge, Meghan S., Melander, Roberta J., Melander, Christian, Johnson, Benjamin K., Abramovitch, Robert B., Basaraba, Randall J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5547695/
https://ncbi.nlm.nih.gov/pubmed/28749949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180925
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