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Small Molecule Adjuvants that Suppress Both Chromosomal and mcr-1 Encoded Colistin-Resistance and Amplify Colistin Efficacy in Polymyxin-Susceptible Bacteria
Bacterial resistance to polymyxin antibiotics has taken on a new and more menacing form. Common are genomically-encoded resistance mechanisms to polymyxins, specifically colistin (polymyxin E), however, the plasmid-borne mobile colistin resistance–1 (mcr-1) gene has recently been identified and pose...
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| Pubblicato in: | Bioorg Med Chem |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5632226/ https://ncbi.nlm.nih.gov/pubmed/28958847 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.08.055 |
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