Small Molecule Adjuvants that Suppress Both Chromosomal and mcr-1 Encoded Colistin-Resistance and Amplify Colistin Efficacy in Polymyxin-Susceptible Bacteria

Bacterial resistance to polymyxin antibiotics has taken on a new and more menacing form. Common are genomically-encoded resistance mechanisms to polymyxins, specifically colistin (polymyxin E), however, the plasmid-borne mobile colistin resistance–1 (mcr-1) gene has recently been identified and pose...

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Publicado en:Bioorg Med Chem
Autores principales: Barker, William T., Martin, Sara E., Chandler, Courtney E., Nguyen, T. Vu, Harris, Tyler L., Goodell, Christopher, Melander, Roberta J., Doi, Yohei, Ernst, Robert K., Melander, Christian
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5632226/
https://ncbi.nlm.nih.gov/pubmed/28958847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.08.055
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