Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer

Por Hussain, Maha, Carducci, Michael A., Slovin, Susan, Cetnar, Jeremy, Qian, Jiang, McKeegan, Evelyn M., Refici-Buhr, Marion, Chyla, Brenda, Shepherd, Stacie P., Giranda, Vincent L., Alumkal, Joshi J.
Publicado no Invest New Drugs (2014)

Genetic biomarkers of sensitivity and resistance to venetoclax monotherapy in patients with relapsed acute myeloid leukemia

Por Chyla, Brenda, Daver, Naval, Doyle, Kelly, McKeegan, Evelyn, Huang, Xin, Ruvolo, Vivian, Wang, Zixing, Chen, Ken, Souers, Andrew, Leverson, Joel, Potluri, Jalaja, Boghaert, Erwin, Bhathena, Anahita, Konopleva, Marina, Popovic, Relja
Publicado no Am J Hematol (2018)

Phase I/II Study of Pemetrexed With or Without ABT-751 in Advanced or Metastatic Non–Small-Cell Lung Cancer

Por Rudin, Charles M., Mauer, Ann, Smakal, Martin, Juergens, Rosalyn, Spelda, Stanislav, Wertheim, Michael, Coates, Andrew, McKeegan, Evelyn, Ansell, Peter, Zhou, Xiangdong, Qian, Jane, Pradhan, Rajendra, Dowell, Barry, Krivoshik, Andrew, Gordon, Gary
Publicado no J Clin Oncol (2011)

EPT-15 A PHASE1/2 CLINICAL TRIAL OF VELIPARIB (ABT-888) AND RADIATION FOLLOWED BY MAINTENANCE THERAPY WITH VELIPARIB AND TEMOZOLOMIDE (TMZ) IN PATIENTS WITH NEWLY DIAGNOSED DIFFUSE...

Por Baxter, Patricia, Su, Jack, Li, Xiao-nan, Thomas, Arzu Onar, Billups, Catherine, Thompson, Patrick, Poussaint, Tina, McKeegan, Evelyn, Wan, Xia, Ansell, Peter, Giranda, Vincent, Paulino, Arnold, Kilburn, Lindsay, Qaddoumi, Ibrahim, Broniscer, Alberto, Blaney, Susan, Boyett, James, Fouladi, Maryam
Publicado no Neuro Oncol (2016)

An open-label, phase 1 study evaluating safety, tolerability, and pharmacokinetics of linifanib (ABT-869) in Japanese patients with solid tumors

Por Asahina, Hajime, Tamura, Yosuke, Nokihara, Hiroshi, Yamamoto, Noboru, Seki, Yoshitaka, Shibata, Takashi, Goto, Yasushi, Tanioka, Maki, Yamada, Yasuhide, Coates, Andrew, Chiu, Yi-Lin, Li, Xiaohui, Pradhan, Rajendra, Ansell, Peter J., McKeegan, Evelyn M., McKee, Mark D., Carlson, Dawn M., Tamura, Tomohide
Publicado em 2012

A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a Pediatric Brain Tumor Consortium report(†)

Por Su, Jack M., Thompson, Patrick, Adesina, Adekunle, Li, Xiao-Nan, Kilburn, Lindsay, Onar-Thomas, Arzu, Kocak, Mehmet, Chyla, Brenda, McKeegan, Evelyn, Warren, Katherine E., Goldman, Stewart, Pollack, Ian F., Fouladi, Maryam, Chen, Alice, Giranda, Vincent, Boyett, James, Kun, Larry, Blaney, Susan M.
Publicado no Neuro Oncol (2014)

Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease

Por Roberts, Andrew W., Seymour, John F., Brown, Jennifer R., Wierda, William G., Kipps, Thomas J., Khaw, Seong Lin, Carney, Dennis A., He, Simon Z., Huang, David C.S., Xiong, Hao, Cui, Yue, Busman, Todd A., McKeegan, Evelyn M., Krivoshik, Andrew P., Enschede, Sari H., Humerickhouse, Rod
Publicado no J Clin Oncol (2012)

Efficacy and Biological Correlates of Response in a Phase 2 Study of Venetoclax Monotherapy in Patients with Acute Myelogenous Leukemia

Por Konopleva, Marina, Pollyea, Daniel A., Potluri, Jalaja, Chyla, Brenda, Hogdal, Leah, Busman, Todd, McKeegan, Evelyn, Salem, Ahmed Hamed, Zhu, Ming, Ricker, Justin L., Blum, William, DiNardo, Courtney D., Kadia, Tapan, Dunbar, Martin, Kirby, Rachel, Falotico, Nancy, Leverson, Joel, Humerickhouse, Rod, Mabry, Mack, Stone, Richard, Kantarjian, Hagop, Letai, Anthony
Publicado no Cancer Discov (2016)

Phase I Study of Navitoclax (ABT-263), a Novel Bcl-2 Family Inhibitor, in Patients With Small-Cell Lung Cancer and Other Solid Tumors

Por Gandhi, Leena, Camidge, D. Ross, Ribeiro de Oliveira, Moacyr, Bonomi, Philip, Gandara, David, Khaira, Divis, Hann, Christine L., McKeegan, Evelyn M., Litvinovich, Elizabeth, Hemken, Philip M., Dive, Caroline, Enschede, Sari H., Nolan, Cathy, Chiu, Yi-Lin, Busman, Todd, Xiong, Hao, Krivoshik, Andrew P., Humerickhouse, Rod, Shapiro, Geoffrey I., Rudin, Charles M.
Publicado no J Clin Oncol (2011)

Randomized Phase II Study of Carboplatin and Paclitaxel With Either Linifanib or Placebo for Advanced Nonsquamous Non–Small-Cell Lung Cancer

Por Ramalingam, Suresh S., Shtivelband, Mikhail, Soo, Ross A., Barrios, Carlos H., Makhson, Anatoly, Segalla, José G.M., Pittman, Kenneth B., Kolman, Petr, Pereira, Jose R., Srkalovic, Gordan, Belani, Chandra P., Axelrod, Rita, Owonikoko, Taofeek K., Qin, Qin, Qian, Jiang, McKeegan, Evelyn M., Devanarayan, Viswanath, McKee, Mark D., Ricker, Justin L., Carlson, Dawn M., Gorbunova, Vera A.
Publicado no J Clin Oncol (2015)

Phase II Study of Single-Agent Navitoclax (ABT-263) and Biomarker Correlates in Patients with Relapsed Small Cell Lung Cancer

Por Rudin, Charles M., Hann, Christine L., Garon, Edward B., Ribeiro de Oliveira, Moacyr, Bonomi, Philip D., Camidge, D. Ross, Chu, Quincy, Giaccone, Giuseppe, Khaira, Divis, Ramalingam, Suresh S., Ranson, Malcolm R., Dive, Caroline, McKeegan, Evelyn M., Chyla, Brenda J., Dowell, Barry L., Chakravartty, Arunava, Nolan, Cathy E., Rudersdorf, Niki, Busman, Todd A., Mabry, Mack H., Krivoshik, Andrew P., Humerickhouse, Rod A., Shapiro, Geoffrey I., Gandhi, Leena
Publicado em 2012