Targeting DNA repair with combination veliparib (ABT-888) and temozolomide in patients with metastatic castration-resistant prostate cancer

Androgen receptor-mediated transcription is directly coupled with the induction of DNA damage, and castration-resistant tumor cells exhibit increased activity of poly (ADP-ribose) polymerase (PARP)-1, a DNA repair enzyme. This study assessed the efficacy and safety of low dose oral PARP inhibitor ve...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Invest New Drugs
Main Authors: Hussain, Maha, Carducci, Michael A., Slovin, Susan, Cetnar, Jeremy, Qian, Jiang, McKeegan, Evelyn M., Refici-Buhr, Marion, Chyla, Brenda, Shepherd, Stacie P., Giranda, Vincent L., Alumkal, Joshi J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4659356/
https://ncbi.nlm.nih.gov/pubmed/24764124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-014-0099-0
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados