A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a Pediatric Brain Tumor Consortium report(†)

BACKGROUND: A phase I trial of veliparib (ABT-888), an oral poly(ADP-ribose) polymerase (PARP) inhibitor, and temozolomide (TMZ) was conducted in children with recurrent brain tumors to (i) estimate the maximum tolerated doses (MTDs) or recommended phase II doses (RP2Ds) of veliparib and TMZ; (ii) d...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Su, Jack M., Thompson, Patrick, Adesina, Adekunle, Li, Xiao-Nan, Kilburn, Lindsay, Onar-Thomas, Arzu, Kocak, Mehmet, Chyla, Brenda, McKeegan, Evelyn, Warren, Katherine E., Goldman, Stewart, Pollack, Ian F., Fouladi, Maryam, Chen, Alice, Giranda, Vincent, Boyett, James, Kun, Larry, Blaney, Susan M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Pediatric Neuro-Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232081/
https://ncbi.nlm.nih.gov/pubmed/24908656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou103
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