Difluoromethylornithine irreversibly inactivates ornithine decarboxylase of Pseudomonas aeruginosa, but does not inhibit the enzymes of Escherichia coli.

Por Kallio, A, McCann, P P
Publicado em 1981

DL-a-Monofluoromethylputrescine is a potent irreversible inhibitor of Escherichia coli ornithine decarboxylase.

Por Kallio, A, McCann, P P, Bey, P
Publicado em 1982

bis(benzyl)polyamine analogues are substrates for a mammalian cell-transport system which is distinct from the polyamine-transport system.

Por Byers, T L, Bitonti, A J, McCann, P P
Publicado em 1990

Regulation of polyamine biosynthesis in rat hepatoma (HTC) cells by a bisbenzyl polyamine analogue.

Por Bitonti, A J, Bush, T L, McCann, P P
Publicado em 1989

Restriction of bacterial growth by inhibition of polyamine biosynthesis by using monofluoromethylornithine, difluoromethylarginine and dicyclohexylammonium sulphate.

Por Bitonti, A J, McCann, P P, Sjoerdsma, A
Publicado em 1982

Suppression of Leishmania donovani by oral administration of a bis(benzyl)polyamine analog.

Por Baumann, R J, McCann, P P, Bitonti, A J
Publicado em 1991

Characterization of Trypanosoma brucei brucei S-adenosyl-L-methionine decarboxylase and its inhibition by Berenil, pentamidine and methylglyoxal bis(guanylhydrazone).

Por Bitonti, A J, Dumont, J A, McCann, P P
Publicado em 1986

Impairment of macrophage function by inhibitors of ornithine decarboxylase activity.

Por Kierszenbaum, F, Wirth, J J, McCann, P P, Sjoerdsma, A
Publicado em 1987

Arginine decarboxylase inhibitors reduce the capacity of Trypanosoma cruzi to infect and multiply in mammalian host cells.

Por Kierszenbaum, F, Wirth, J J, McCann, P P, Sjoerdsma, A
Publicado em 1987

Effects of alpha-difluoromethylornithine on protein synthesis and synthesis of the variant-specific glycoprotein (VSG) in Trypanosoma brucei brucei.

Por Bitonti, A J, Cross-Doersen, D E, McCann, P P
Publicado em 1988

Antitrypanosomal effects of polyamine biosynthesis inhibitors correlate with increases in Trypanosoma brucei brucei S-adenosyl-L-methionine.

Por Byers, T L, Bush, T L, McCann, P P, Bitonti, A J
Publicado em 1991

Catalytic irreversible inhibition of bacterial and plant arginine decarboxylase activities by novel substrate and product analogues.

Por Bitonti, A J, Casara, P J, McCann, P P, Bey, P
Publicado em 1987

DL-alpha-difluoromethyl[3,4-3H]arginine metabolism in tobacco and mammalian cells. Inhibition of ornithine decarboxylase activity after arginase-mediated hydrolysis of DL-alpha-dif...

Por Slocum, R D, Bitonti, A J, McCann, P P, Feirer, R P
Publicado em 1988

Alpha-methyl ornithine, a potent competitive inhibitor of ornithine decarboxylase, blocks proliferation of rat hepatoma cells in culture.

Por Mamont, P S, Böhlen, P, McCann, P P, Bey, P, Schuber, F, Tardif, C
Publicado em 1976

Suppression of both antimony-susceptible and antimony-resistant Leishmania donovani by a bis(benzyl)polyamine analog.

Por Baumann, R J, Hanson, W L, McCann, P P, Sjoerdsma, A, Bitonti, A J
Publicado em 1990

Polyamine biosynthesis is required for the maintenance of peripheral blood cell elements in the rat.

Por Luk, G D, Sharkis, S J, Abeloff, M D, McCann, P P, Sjoerdsma, A, Baylin, S B
Publicado em 1983

Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.

Por Clarkson, A B, Bacchi, C J, Mellow, G H, Nathan, H C, McCann, P P, Sjoerdsma, A
Publicado em 1983

Cure of murine Trypanosoma brucei rhodesiense infections with an S-adenosylmethionine decarboxylase inhibitor.

Por Bacchi, C J, Nathan, H C, Yarlett, N, Goldberg, B, McCann, P P, Bitonti, A J, Sjoerdsma, A
Publicado em 1992

Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornith...

Por Bitonti, A J, Dumont, J A, Bush, T L, Edwards, M L, Stemerick, D M, McCann, P P, Sjoerdsma, A
Publicado em 1989

Combination chemotherapy of drug-resistant Trypanosoma brucei rhodesiense infections in mice using DL-alpha-difluoromethylornithine and standard trypanocides.

Por Bacchi, C J, Nathan, H C, Yarlett, N, Goldberg, B, McCann, P P, Sjoerdsma, A, Saric, M, Clarkson, A B
Publicado em 1994