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Bis(benzyl)polyamine analogs inhibit the growth of chloroquine-resistant human malaria parasites (Plasmodium falciparum) in vitro and in combination with alpha-difluoromethylornithine cure murine malaria.

A number of bis(benzyl)polyamine analogs were found to be potent inhibitors of both chloroquine-resistant and chloroquine-sensitive strains of the human malaria parasite Plasmodium falciparum in vitro (IC50 values = 0.2-14 microM). Administration of one of the compounds, MDL 27695, which is N,N'-bis...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Bitonti, A J, Dumont, J A, Bush, T L, Edwards, M L, Stemerick, D M, McCann, P P, Sjoerdsma, A
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC286531/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2463635/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.2.651
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