What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans?: Rigorous Simian Immunodeficiency Virus Vaccine Trials Can Be Instructive

Por Martins, Mauricio A., Watkins, David I.
Publicado no Cold Spring Harb Perspect Biol (2018)

Nef Is Dispensable for Resistance of Simian Immunodeficiency Virus-Infected Macrophages to CD8(+) T Cell Killing

Por Rainho, Jennifer N., Martins, Mauricio A., Cunyat, Francesc, Watkins, Ian T., Watkins, David I., Stevenson, Mario
Publicado no J Virol (2015)

T-Cell Correlates of Vaccine Efficacy after a Heterologous Simian Immunodeficiency Virus Challenge

Por Martins, Mauricio A., Wilson, Nancy A., Reed, Jason S., Ahn, Chanook D., Klimentidis, Yann C., Allison, David B., Watkins, David I.
Publicado em 2010

Analysis of Simian Immunodeficiency Virus-specific CD8(+) T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining

Por Gonzalez-Nieto, Lucas, Domingues, Aline, Ricciardi, Michael, Gutman, Martin J., Maxwell, Helen S., Pedreño-Lopez, Nuria, Bailey, Varian, Magnani, Diogo M., Martins, Mauricio A.
Publicado no J Vis Exp (2016)

A recombinant herpesviral vector containing a near-full-length SIVmac239 genome produces SIV particles and elicits immune responses to all nine SIV gene products

Por Shin, Young C., Bischof, Georg F., Lauer, William A., Gonzalez-Nieto, Lucas, Rakasz, Eva G., Hendricks, Gregory M., Watkins, David I., Martins, Mauricio A., Desrosiers, Ronald C.
Publicado no PLoS Pathog (2018)

Vaccine protection against SIVmac239 acquisition

Por Martins, Mauricio A., Bischof, Georg F., Shin, Young C., Lauer, William A., Gonzalez-Nieto, Lucas, Watkins, David I., Rakasz, Eva G., Lifson, Jeffrey D., Desrosiers, Ronald C.
Publicado no Proc Natl Acad Sci U S A (2019)

The Majority of Freshly Sorted Simian Immunodeficiency Virus (SIV)-Specific CD8(+) T Cells Cannot Suppress Viral Replication in SIV-Infected Macrophages

Por Vojnov, Lara, Martins, Mauricio A., Bean, Alexander T., Veloso de Santana, Marlon G., Sacha, Jonah B., Wilson, Nancy A., Bonaldo, Myrna C., Galler, Ricardo, Stevenson, Mario, Watkins, David I.
Publicado em 2012

A Recombinant Rhesus Monkey Rhadinovirus Deleted of Glycoprotein L Establishes Persistent Infection of Rhesus Macaques and Elicits Conventional T Cell Responses

Por Hahn, Alexander S., Bischof, Georg F., Großkopf, Anna K., Shin, Young C., Domingues, Aline, Gonzalez-Nieto, Lucas, Rakasz, Eva G., Watkins, David I., Ensser, Armin, Martins, Mauricio A., Desrosiers, Ronald C.
Publicado no J Virol (2020)

CD8(+) gamma-delta TCR(+) and CD4(+) T cells produce IFN-γat 5–7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T...

Por Neves, Patrícia C. C., Rudersdorf, Richard A., Galler, Ricardo, Bonaldo, Myrna C., de Santana, Marlon Gilsepp Veloso, Mudd, Philip A., Martins, Maurício A., Rakasz, Eva G., Wilson, Nancy A., Watkins, David I.
Publicado em 2010

Gag- and Nef-specific CD4(+) T cells recognize and inhibit SIV replication in infected macrophages early after infection

Por Sacha, Jonah B., Giraldo-Vela, Juan P., Buechler, Matthew B., Martins, Mauricio A., Maness, Nicholas J., Chung, Chungwon, Wallace, Lyle T., León, Enrique J., Friedrich, Thomas C., Wilson, Nancy A., Hiraoka, Atsunobu, Watkins, David I.
Publicado em 2009

Effector function does not contribute to protection from virus challenge by a highly potent HIV broadly neutralizing antibody in nonhuman primates.*

Por Hangartner, Lars, Beauparlant, David, Rakasz, Eva, Nedellec, Rebecca, Hozé, Nathanaël, McKenney, Katherine, Martins, Mauricio A., Seabright, Gemma E., Allen, Joel D., Weiler, Andrea M., Friedrich, Thomas C., Regoes, Roland R., Crispin, Max, Burton, Dennis R.
Publicado no Sci Transl Med (2021)

Non-neutralizing Antibodies May Contribute to Suppression of SIVmac239 Viremia in Indian Rhesus Macaques

Por Pedreño-Lopez, Nuria, Rosen, Brandon C., Flores, Walter J., Gorman, Matthew J., Voigt, Thomas B., Ricciardi, Michael J., Crosno, Kristin, Weisgrau, Kim L., Parks, Christopher L., Lifson, Jeffrey D., Alter, Galit, Rakasz, Eva G., Magnani, Diogo M., Martins, Mauricio A., Watkins, David I.
Publicado no Front Immunol (2021)

Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8(+) T-Cell Responses in Rhesus Macaques

Por Bonaldo, Myrna C., Martins, Mauricio A., Rudersdorf, Richard, Mudd, Philip A., Sacha, Jonah B., Piaskowski, Shari M., Costa Neves, Patrícia C., Veloso de Santana, Marlon G., Vojnov, Lara, Capuano, Saverio, Rakasz, Eva G., Wilson, Nancy A., Fulkerson, John, Sadoff, Jerald C., Watkins, David I., Galler, Ricardo
Publicado em 2010

Rectal Acquisition of Simian Immunodeficiency Virus (SIV) SIVmac239 Infection despite Vaccine-Induced Immune Responses against the Entire SIV Proteome

Por Martins, Mauricio A., Gonzalez-Nieto, Lucas, Ricciardi, Michael J., Bailey, Varian K., Dang, Christine M., Bischof, Georg F., Pedreño-Lopez, Nuria, Pauthner, Matthias G., Burton, Dennis R., Parks, Christopher L., Earl, Patricia, Moss, Bernard, Rakasz, Eva G., Lifson, Jeffrey D., Desrosiers, Ronald C., Watkins, David I.
Publicado no J Virol (2020)

Vaccine protection against rectal acquisition of SIVmac239 in rhesus macaques

Por Gonzalez-Nieto, Lucas, Castro, Isabelle M., Bischof, Georg F., Shin, Young C., Ricciardi, Michael J., Bailey, Varian K., Dang, Christine M., Pedreño-Lopez, Nuria, Magnani, Diogo M., Ejima, Keisuke, Allison, David B., Gil, Hwi Min, Evans, David T., Rakasz, Eva G., Lifson, Jeffrey D., Desrosiers, Ronald C., Martins, Mauricio A.
Publicado no PLoS Pathog (2019)

Immunogenicity of Seven New Recombinant Yellow Fever Viruses 17D Expressing Fragments of SIVmac239 Gag, Nef, and Vif in Indian Rhesus Macaques

Por Martins, Mauricio A., Bonaldo, Myrna C., Rudersdorf, Richard A., Piaskowski, Shari M., Rakasz, Eva G., Weisgrau, Kim L., Furlott, Jessica R., Eernisse, Christopher M., Veloso de Santana, Marlon G., Hidalgo, Bertha, Friedrich, Thomas C., Chiuchiolo, Maria J., Parks, Christopher L., Wilson, Nancy A., Allison, David B., Galler, Ricardo, Watkins, David I.
Publicado em 2013

Vaccination with gag, vif, and nef Gene Fragments Affords Partial Control of Viral Replication after Mucosal Challenge with SIVmac239

Por Martins, Mauricio A., Wilson, Nancy A., Piaskowski, Shari M., Weisgrau, Kim L., Furlott, Jessica R., Bonaldo, Myrna C., Veloso de Santana, Marlon G., Rudersdorf, Richard A., Rakasz, Eva G., Keating, Karen D., Chiuchiolo, Maria J., Piatak, Michael, Allison, David B., Parks, Christopher L., Galler, Ricardo, Lifson, Jeffrey D., Watkins, David I.
Publicado em 2014

The Frequency of Vaccine-Induced T-Cell Responses Does Not Predict the Rate of Acquisition after Repeated Intrarectal SIVmac239 Challenges in Mamu-B*08(+) Rhesus Macaques

Por Martins, Mauricio A., Gonzalez-Nieto, Lucas, Shin, Young C., Domingues, Aline, Gutman, Martin J., Maxwell, Helen S., Magnani, Diogo M., Ricciardi, Michael J., Pedreño-Lopez, Núria, Bailey, Varian K., Altman, John D., Parks, Christopher L., Allison, David B., Ejima, Keisuke, Rakasz, Eva G., Capuano, Saverio, Desrosiers, Ronald C., Lifson, Jeffrey D., Watkins, David I.
Publicado no J Virol (2019)

Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8(+) T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection

Por Martins, Mauricio A., Tully, Damien C., Cruz, Michael A., Power, Karen A., Veloso de Santana, Marlon G., Bean, David J., Ogilvie, Colin B., Gadgil, Rujuta, Lima, Noemia S., Magnani, Diogo M., Ejima, Keisuke, Allison, David B., Piatak, Michael, Altman, John D., Parks, Christopher L., Rakasz, Eva G., Capuano, Saverio, Galler, Ricardo, Bonaldo, Myrna C., Lifson, Jeffrey D., Allen, Todd M., Watkins, David I.
Publicado no J Virol (2015)

Induction of Transient Virus Replication Facilitates Antigen-Independent Isolation of SIV-Specific Monoclonal Antibodies

Por Pedreño-Lopez, Nuria, Dang, Christine M., Rosen, Brandon C., Ricciardi, Michael J., Bailey, Varian K., Gutman, Martin J., Gonzalez-Nieto, Lucas, Pauthner, Matthias G., Le, Khoa, Song, Ge, Andrabi, Raiees, Weisgrau, Kim L., Pomplun, Nicholas, Martinez-Navio, José M., Fuchs, Sebastian P., Wrammert, Jens, Rakasz, Eva G., Lifson, Jeffrey D., Martins, Mauricio A., Burton, Dennis R., Watkins, David I., Magnani, Diogo M.
Publicado no Mol Ther Methods Clin Dev (2020)