Gag- and Nef-specific CD4(+) T cells recognize and inhibit SIV replication in infected macrophages early after infection

The precise immunological role played by CD4(+) T cells in retroviral infections is poorly defined. Here, we describe a new function of these cells, the elimination of retrovirus-infected macrophages. After experimental CD8(+) cell depletion, elite controlling macaques with set-point viral loads ≤50...

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Detalhes bibliográficos
Main Authors: Sacha, Jonah B., Giraldo-Vela, Juan P., Buechler, Matthew B., Martins, Mauricio A., Maness, Nicholas J., Chung, Chungwon, Wallace, Lyle T., León, Enrique J., Friedrich, Thomas C., Wilson, Nancy A., Hiraoka, Atsunobu, Watkins, David I.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2687996/
https://ncbi.nlm.nih.gov/pubmed/19478057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813106106
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