Pol-Specific CD8(+) T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I Downregulation

Effective, vaccine-induced CD8(+) T-cell responses should recognize infected cells early enough to prevent production of progeny virions. We have recently shown that Gag-specific CD8(+) T cells recognize simian immunodeficiency virus-infected cells at 2 h postinfection, whereas Env-specific CD8(+) T...

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Detalhes bibliográficos
Main Authors: Sacha, Jonah B., Chung, Chungwon, Reed, Jason, Jonas, Anna K., Bean, Alexander T., Spencer, Sean P., Lee, Wonhee, Vojnov, Lara, Rudersdorf, Richard, Friedrich, Thomas C., Wilson, Nancy A., Lifson, Jeffrey D., Watkins, David I.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168778/
https://ncbi.nlm.nih.gov/pubmed/17699580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00926-07
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