Pol-Specific CD8(+) T Cells Recognize Simian Immunodeficiency Virus-Infected Cells Prior to Nef-Mediated Major Histocompatibility Complex Class I Downregulation

Effective, vaccine-induced CD8(+) T-cell responses should recognize infected cells early enough to prevent production of progeny virions. We have recently shown that Gag-specific CD8(+) T cells recognize simian immunodeficiency virus-infected cells at 2 h postinfection, whereas Env-specific CD8(+) T...

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Dades bibliogràfiques
Autors principals: Sacha, Jonah B., Chung, Chungwon, Reed, Jason, Jonas, Anna K., Bean, Alexander T., Spencer, Sean P., Lee, Wonhee, Vojnov, Lara, Rudersdorf, Richard, Friedrich, Thomas C., Wilson, Nancy A., Lifson, Jeffrey D., Watkins, David I.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology (ASM) 2007
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168778/
https://ncbi.nlm.nih.gov/pubmed/17699580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00926-07
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