A Recombinant Rhesus Monkey Rhadinovirus Deleted of Glycoprotein L Establishes Persistent Infection of Rhesus Macaques and Elicits Conventional T Cell Responses

A replication-competent, recombinant strain of rhesus monkey rhadinovirus (RRV) expressing the Gag protein of SIVmac239 was constructed in the context of a glycoprotein L (gL) deletion mutation. Deletion of gL detargets the virus from Eph family receptors. The ability of this gL-minus Gag recombinan...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Hahn, Alexander S., Bischof, Georg F., Großkopf, Anna K., Shin, Young C., Domingues, Aline, Gonzalez-Nieto, Lucas, Rakasz, Eva G., Watkins, David I., Ensser, Armin, Martins, Mauricio A., Desrosiers, Ronald C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2020
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6955260/
https://ncbi.nlm.nih.gov/pubmed/31645449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01093-19
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