The Majority of Freshly Sorted Simian Immunodeficiency Virus (SIV)-Specific CD8(+) T Cells Cannot Suppress Viral Replication in SIV-Infected Macrophages

Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) primarily infect activated CD4(+) T cells but can infect macrophages. Surprisingly, ex vivo tetramer-sorted SIV-specific CD8(+) T cells that eliminated and suppressed viral replication in SIV-infected CD4(+) T cells failed to...

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Main Authors: Vojnov, Lara, Martins, Mauricio A., Bean, Alexander T., Veloso de Santana, Marlon G., Sacha, Jonah B., Wilson, Nancy A., Bonaldo, Myrna C., Galler, Ricardo, Stevenson, Mario, Watkins, David I.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Pathogenesis and Immunity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3318662/
https://ncbi.nlm.nih.gov/pubmed/22318140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06324-11
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