Letter by Teerlink et al Regarding Article, “The Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myos...

Por Teerlink, John R., Malik, Fady I., Kass, David A.
Publicado no Circ Heart Fail (2015)

A Double-Blinded, Randomized, Placebo-Controlled Trial to Evaluate Efficacy, Safety, and Tolerability of Single Doses of Tirasemtiv in Patients with Acetylcholine Receptor-Binding...

Por Sanders, Donald B., Rosenfeld, Jeffrey, Dimachkie, Mazen M., Meng, Lisa, Malik, Fady I.
Publicado no Neurotherapeutics (2015)

Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

Por Planelles-Herrero, Vicente J., Hartman, James J., Robert-Paganin, Julien, Malik, Fady I., Houdusse, Anne
Publicado no Nat Commun (2017)

Fast Skeletal Muscle Troponin Activation Increases Force of Mouse Fast Skeletal Muscle and Ameliorates Weakness Due to Nebulin-Deficiency

Por Lee, Eun-Jeong, De Winter, Josine M., Buck, Danielle, Jasper, Jeffrey R., Malik, Fady I., Labeit, Siegfried, Ottenheijm, Coen A., Granzier, Henk
Publicado em 2013

Fast Skeletal Muscle Troponin Activator tirasemtiv Increases Muscle Function and Performance in the B6SJL-SOD1(G93A) ALS Mouse Model

Por Hwee, Darren T., Kennedy, Adam, Ryans, Julie, Russell, Alan J., Jia, Zhiheng, Hinken, Aaron C., Morgans, David J., Malik, Fady I., Jasper, Jeffrey R.
Publicado em 2014

Incorporating development of a patient-reported outcome instrument in a clinical drug development program: examples from a heart failure program

Por Wiklund, Ingela, Anatchkova, Milena, Oko-Osi, Hafiz, von Maltzahn, Robyn, Chau, Dina, Malik, Fady I., Patrick, Donald L., Spertus, John, Teerlink, John R.
Publicado no Health Qual Life Outcomes (2016)

Inhibition of Smooth Muscle Myosin as a Novel Therapeutic Target for Hypertension

Por Zhao, Xin, Ho, David, Abarzúa, Patricio, Dhar, Sunil K., Wang, Xi, Jia, Zhiheng, Pannirselvam, Malar, Morgans, David J., Malik, Fady I., Vatner, Stephen F.
Publicado em 2011

Smooth Muscle Myosin Inhibition: A Novel Therapeutic Approach for Pulmonary Hypertension

Por Ho, David, Chen, Li, Zhao, Xin, Durham, Nicquanna, Pannirselvam, Malar, Vatner, Dorothy E., Morgans, David J., Malik, Fady I., Vatner, Stephen F., Shen, You-Tang
Publicado em 2012

The Ca(2+) sensitizer CK‐2066260 increases myofibrillar Ca(2+) sensitivity and submaximal force selectively in fast skeletal muscle

Por Hwee, Darren T., Cheng, Arthur J., Hartman, James J., Hinken, Aaron C., Lee, Ken, Durham, Nickie, Russell, Alan J., Malik, Fady I., Westerblad, Håkan, Jasper, Jeffrey R.
Publicado no J Physiol (2017)

Tirasemtiv amplifies skeletal muscle response to nerve activation in humans

Por Hansen, Richard, Saikali, Khalil G, Chou, Willis, Russell, Alan J, Chen, Michael M, Vijayakumar, Vipin, Stoltz, Randall R, Baudry, Stephane, Enoka, Roger M, Morgans, David J, Wolff, Andrew A, Malik, Fady I
Publicado no Muscle Nerve (2014)

Troponin activator augments muscle force in nemaline myopathy patients with nebulin mutations

Por de Winter, Josine Marieke, Buck, Danielle, Hidalgo, Carlos, Jasper, Jeffrey R, Malik, Fady I, Clarke, Nigel F, Stienen, Ger J M, Lawlor, Michael W, Beggs, Alan H, Ottenheijm, Coen A C, Granzier, Henk
Publicado em 2013

Reduced force of diaphragm muscle fibers in patients with chronic thromboembolic pulmonary hypertension

Por Manders, Emmy, Bonta, Peter I., Kloek, Jaap J., Symersky, Petr, Bogaard, Harm-Jan, Hooijman, Pleuni E., Jasper, Jeff R., Malik, Fady I., Stienen, Ger J. M., Vonk-Noordegraaf, Anton, de Man, Frances S., Ottenheijm, Coen A. C.
Publicado no Am J Physiol Lung Cell Mol Physiol (2016)

Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy

Por Ottenheijm, Coen A. C., Buck, Danielle, de Winter, Josine M., Ferrara, Claudia, Piroddi, Nicoletta, Tesi, Chiara, Jasper, Jeffrey R., Malik, Fady I., Meng, Hui, Stienen, Ger J. M., Beggs, Alan H., Labeit, Siegfried, Poggesi, Corrado, Lawlor, Michael W., Granzier, Henk
Publicado em 2013

Highly selective inhibition of myosin motors provides the basis of potential therapeutic application

Por Sirigu, Serena, Hartman, James J., Planelles-Herrero, Vicente José, Ropars, Virginie, Clancy, Sheila, Wang, Xi, Chuang, Grace, Qian, Xiangping, Lu, Pu-Ping, Barrett, Edward, Rudolph, Karin, Royer, Christopher, Morgan, Bradley P., Stura, Enrico A., Malik, Fady I., Houdusse, Anne M.
Publicado no Proc Natl Acad Sci U S A (2016)

Discovery of Omecamtiv Mecarbil the First, Selective, Small Molecule Activator of Cardiac Myosin

Por Morgan, Bradley P., Muci, Alexander, Lu, Pu-Ping, Qian, Xiangping, Tochimoto, Todd, Smith, Whitney W., Garard, Marc, Kraynack, Erica, Collibee, Scott, Suehiro, Ion, Tomasi, Adam, Valdez, S. Corey, Wang, Wenyue, Jiang, Hong, Hartman, James, Rodriguez, Hector M., Kawas, Raja, Sylvester, Sheila, Elias, Kathleen A., Godinez, Guillermo, Lee, Kenneth, Anderson, Robert, Sueoka, Sandra, Xu, Donghong, Wang, Zhengping, Djordjevic, Nebojsa, Malik, Fady I., Morgans, David J.
Publicado em 2010

Diaphragm Fiber Strength Is Reduced in Critically Ill Patients and Restored by a Troponin Activator

Por Hooijman, Pleuni E., Beishuizen, Albertus, de Waard, Monique C., de Man, Frances S., Vermeijden, J. W., Steenvoorde, Pascal, Bouwman, R. Arthur, Lommen, Wies, van Hees, Hieronymus W.H., Heunks, Leo M.A., Dickhoff, Chris, van der Peet, Donald L., Girbes, Armand R. J., Jasper, Jeff R., Malik, Fady I., Stienen, Ger J.M., Hartemink, Koen J., Paul, Marinus A., Ottenheijm, Coen A.C.
Publicado no Am J Respir Crit Care Med (2014)

Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases

Por Russell, Alan J, Hartman, James J, Hinken, Aaron C, Muci, Alexander R, Kawas, Raja, Driscoll, Lena, Godinez, Guillermo, Lee, Kenneth H, Marquez, David, Browne, William F, Chen, Michael M, Clarke, David, Collibee, Scott E, Garard, Marc, Hansen, Richard, Jia, Zhiheng, Lu, Pu-Ping, Rodriguez, Hector, Saikali, Khalil G, Schaletzky, Julia, Vijayakumar, Vipin, Albertus, Daniel L, Claflin, Dennis R, Morgans, David J, Morgan, Bradley P, Malik, Fady I
Publicado em 2012

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

Por Malik, Fady I., Hartman, James J., Elias, Kathleen A., Morgan, Bradley P., Rodriguez, Hector, Brejc, Katjuša, Anderson, Robert L., Sueoka, Sandra H., Lee, Kenneth H., Finer, Jeffrey T., Sakowicz, Roman, Baliga, Ramesh, Cox, David R., Garard, Marc, Godinez, Guillermo, Kawas, Raja, Kraynack, Erica, Lenzi, David, Lu, Pu Ping, Muci, Alexander, Niu, Congrong, Qian, Xiangping, Pierce, Daniel W., Pokrovskii, Maria, Suehiro, Ion, Sylvester, Sheila, Tochimoto, Todd, Valdez, Corey, Wang, Wenyue, Katori, Tatsuo, Kass, David A., Shen, You-Tang, Vatner, Stephen F., Morgans, David J.
Publicado em 2011