Inhibition of Smooth Muscle Myosin as a Novel Therapeutic Target for Hypertension

We examined a novel therapeutic approach for hypertension, a small-molecule direct inhibitor of smooth muscle myosin, CK-2018448 (CK-448), which is an N,N'-alkylurea (U.S. Patent Publication 2009–0275537 A1) in conscious dogs with renal hypertension and compared its efficacy with that of a calc...

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Detalhes bibliográficos
Main Authors: Zhao, Xin, Ho, David, Abarzúa, Patricio, Dhar, Sunil K., Wang, Xi, Jia, Zhiheng, Pannirselvam, Malar, Morgans, David J., Malik, Fady I., Vatner, Stephen F.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
Assuntos:
Cardiovascular
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186291/
https://ncbi.nlm.nih.gov/pubmed/21784887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.182402
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