Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

Decreased cardiac contractility is a central feature of systolic heart failure. Existing drugs increase cardiac contractility indirectly through signaling cascades but are limited by their mechanism-related adverse effects. To avoid these limitations, we previously developed omecamtiv mecarbil, a sm...

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Detalhes bibliográficos
Main Authors: Malik, Fady I., Hartman, James J., Elias, Kathleen A., Morgan, Bradley P., Rodriguez, Hector, Brejc, Katjuša, Anderson, Robert L., Sueoka, Sandra H., Lee, Kenneth H., Finer, Jeffrey T., Sakowicz, Roman, Baliga, Ramesh, Cox, David R., Garard, Marc, Godinez, Guillermo, Kawas, Raja, Kraynack, Erica, Lenzi, David, Lu, Pu Ping, Muci, Alexander, Niu, Congrong, Qian, Xiangping, Pierce, Daniel W., Pokrovskii, Maria, Suehiro, Ion, Sylvester, Sheila, Tochimoto, Todd, Valdez, Corey, Wang, Wenyue, Katori, Tatsuo, Kass, David A., Shen, You-Tang, Vatner, Stephen F., Morgans, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4090309/
https://ncbi.nlm.nih.gov/pubmed/21415352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1200113
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