Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator

[Image: see text] The identification and optimization of the first activators of fast skeletal muscle are reported. Compound 1 was identified from high-throughput screening (HTS) and subsequently found to improve muscle function via interaction with the troponin complex. Optimization of 1 for potenc...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Collibee, Scott E., Bergnes, Gustave, Muci, Alexander, Browne, William F., Garard, Marc, Hinken, Aaron C., Russell, Alan J., Suehiro, Ion, Hartman, James, Kawas, Raja, Lu, Pu-Ping, Lee, Kenneth H., Marquez, David, Tomlinson, Matthew, Xu, Donghong, Kennedy, Adam, Hwee, Darren, Schaletzky, Julia, Leung, Kwan, Malik, Fady I., Morgans, David J., Morgan, Bradley P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2018
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900333/
https://ncbi.nlm.nih.gov/pubmed/29670700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00546
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