Fast Skeletal Muscle Troponin Activation Increases Force of Mouse Fast Skeletal Muscle and Ameliorates Weakness Due to Nebulin-Deficiency

The effect of the fast skeletal muscle troponin activator, CK-2066260, on calcium-induced force development was studied in skinned fast skeletal muscle fibers from wildtype (WT) and nebulin deficient (NEB KO) mice. Nebulin is a sarcomeric protein that when absent (NEB KO mouse) or present at low lev...

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Détails bibliographiques
Auteurs principaux: Lee, Eun-Jeong, De Winter, Josine M., Buck, Danielle, Jasper, Jeffrey R., Malik, Fady I., Labeit, Siegfried, Ottenheijm, Coen A., Granzier, Henk
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3577798/
https://ncbi.nlm.nih.gov/pubmed/23437068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0055861
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