Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

Por Planelles-Herrero, Vicente J., Hartman, James J., Robert-Paganin, Julien, Malik, Fady I., Houdusse, Anne
Publicado no Nat Commun (2017)

Supraphysiological levels of GDF11 induce striated muscle atrophy

Por Hammers, David W, Merscham‐Banda, Melissa, Hsiao, Jennifer Ying, Engst, Stefan, Hartman, James J, Sweeney, H Lee
Publicado no EMBO Mol Med (2017)

The Ca(2+) sensitizer CK‐2066260 increases myofibrillar Ca(2+) sensitivity and submaximal force selectively in fast skeletal muscle

Por Hwee, Darren T., Cheng, Arthur J., Hartman, James J., Hinken, Aaron C., Lee, Ken, Durham, Nickie, Russell, Alan J., Malik, Fady I., Westerblad, Håkan, Jasper, Jeffrey R.
Publicado no J Physiol (2017)

Highly selective inhibition of myosin motors provides the basis of potential therapeutic application

Por Sirigu, Serena, Hartman, James J., Planelles-Herrero, Vicente José, Ropars, Virginie, Clancy, Sheila, Wang, Xi, Chuang, Grace, Qian, Xiangping, Lu, Pu-Ping, Barrett, Edward, Rudolph, Karin, Royer, Christopher, Morgan, Bradley P., Stura, Enrico A., Malik, Fady I., Houdusse, Anne M.
Publicado no Proc Natl Acad Sci U S A (2016)

Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases

Por Russell, Alan J, Hartman, James J, Hinken, Aaron C, Muci, Alexander R, Kawas, Raja, Driscoll, Lena, Godinez, Guillermo, Lee, Kenneth H, Marquez, David, Browne, William F, Chen, Michael M, Clarke, David, Collibee, Scott E, Garard, Marc, Hansen, Richard, Jia, Zhiheng, Lu, Pu-Ping, Rodriguez, Hector, Saikali, Khalil G, Schaletzky, Julia, Vijayakumar, Vipin, Albertus, Daniel L, Claflin, Dennis R, Morgans, David J, Morgan, Bradley P, Malik, Fady I
Publicado em 2012

Cardiac Myosin Activation: A Potential Therapeutic Approach for Systolic Heart Failure

Por Malik, Fady I., Hartman, James J., Elias, Kathleen A., Morgan, Bradley P., Rodriguez, Hector, Brejc, Katjuša, Anderson, Robert L., Sueoka, Sandra H., Lee, Kenneth H., Finer, Jeffrey T., Sakowicz, Roman, Baliga, Ramesh, Cox, David R., Garard, Marc, Godinez, Guillermo, Kawas, Raja, Kraynack, Erica, Lenzi, David, Lu, Pu Ping, Muci, Alexander, Niu, Congrong, Qian, Xiangping, Pierce, Daniel W., Pokrovskii, Maria, Suehiro, Ion, Sylvester, Sheila, Tochimoto, Todd, Valdez, Corey, Wang, Wenyue, Katori, Tatsuo, Kass, David A., Shen, You-Tang, Vatner, Stephen F., Morgans, David J.
Publicado em 2011